Human Sera
Cayman Chemical Olmesartn MedoxomIl 50mg
A prodrug form of olmesartan; inhibits the angiotensin II pressor response in normotensive rats at 0.1 mg/kg; reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, at 10 mg/kg per day, as well as in chow-fed control animals at 11.4 mg/kg per day; inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats
Cayman Chemical 2deoxyDGlucose6phosphate 100mg
A derivative of 2-DG that is produced in mammalian cells by the action of hexokinase; accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death
Cayman Chemical BalsalazIde 50mg
A prodrug form of 5-ASA; cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA; decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of DNCB-induced colitis at 600 mg/kg per day
Cayman Chemical DaclatsvIr 100mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical PodophylotoxIn 100mg
A lignan with diverse biological activities; inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM); induces mitotic arrest at the G2/M phase in CCRF CEM cells from 0.01 to 5 UG/ml; is protective against HSV-1 infection in Vero cells at 5 µM; inhibits proliferation of several DLBCL cell lines (IC50s = 0.0098-0.017 µM); a starting material in the semisynthesis of etoposide and teniposide
Cayman Chemical TerbuthylazIn 100mg
A triazine herbicide; active against a variety of broadleaf and grass weeds in combination with S-metolachlor; has been found in surface groundwater and soil samples
Cayman Chemical 7Benzyloxy4 trIfluoromthy 50mg
A fluorogenic substrate for CYP1A2 and CYP3A; HFC is released upon enzymatic cleavage by CYP1A2 and CYP3A and its fluorescence can be used to quantify CYP activity; ex/em = 410/510 nm, respectively
Cayman Chemical Methotrexatehydrate 100mg
A folic acid and aminopterin derivative; inhibits folic acid metabolism; inhibits purine and pyrimidine synthesis, blocking cell proliferation; induces adenosine release; has anti-inflammatory effects; has been considered the gold standard of DMARD therapy for the immune-inflammatory and joint destructive processes of rheumatoid arthritis
Cayman Chemical PImonIdazole 50mg
A small molecule radiosensitizer that has proven to be an effective and nontoxic immunochemical hypoxia marker for human squamous cell carcinomas of the cervix, head and neck
Cayman Chemical Forchlorfenuron 100mg
A plant growth regulator; stimulates fruit growth, as well as increases fruit size and ripening rate, in kiwifruit when applied topically at 40 mg/L; accelerates fruit growth and increases rind thickness in watermelons
Cayman Chemical AcetophenazInmaleate 100mg
A typical antipsychotic; binds to 5-HT6 and 5-HT7 receptors and the androgen receptor (Kis = 72, 2.4, and 800 nM, respectively); inhibits the binding of SKF 10047 (Ki = 36 nM) and spiperone (IC50 = 17 nM) to guinea pig brain membranes; increases the duration of fighting and the latency to submission in mice
Cayman Chemical SulconazolenItrate 100mg
An azole antifungal; active against dermatophyte fungal species, including isolates of various Candida species; non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes; inhibits various CYP450 isoforms in human lymphoblast microsomes in vitro (Kis = 0.008-3.5 µM); inhibits heme oxygenase 1 activity in rat spleen microsomes (IC50 = 1.1 µM); inhibits DNA damage induced by styrene metabolism by bacterial CYP450cam (Ki = 204.2 μM)
Cayman Chemical 2 4DImethylmethcathInonhy 50mg
A disubstituted analog of methcathinone; intended for research and forensic purposes
Cayman Chemical PterostIlben 50mg
A stilbene with diverse biological activities; reduces acifluorfen-induced photooxidative leakage in C. sativus cotyledon disks at 30 UG/ml; inhibits TPA-induced invasion and migration of HepG2 cells at 25 and 50 µM; inhibits production of NO and PGE2 in LPS-stimulated RAW 264.7 macrophages at 10 and 20 µM; activates PPARα in H4IIEC3 cells at 100 and 300 µM; decreases plasma glucose and LDL levels and increases plasma HDL levels in a hamster model of high-fat diet-induced hypercholesterolemia at 25 ppm in the diet
